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420 Columbus Cannabis — Dispensary in Columbus, Mississippi

2118 Hwy 45 N, Columbus, Mississippi 39705

4.8· 15 reviews

Best Dispensaries in Columbus · WeedDispos Score 63/100 →

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Overview

420 Columbus Cannabis is a dual-licensed dispensary located at 2118 Hwy 45 N in Columbus, Mississippi. The shop holds a 4.8-star rating from 15 Google reviews and a 5-star rating from 43 reviews on Weedmaps. Its inventory includes products from brands such as Delta Bud Company, Southern Sky Brands, Sweet Life Canna Co, MidSouth Extracts, Noble Labs, Gruv, and Good Day Farm. Customers should note that the store is open daily from 9:00 a.m. to 7:00 p.m., except on Sundays when it closes at 6:00 p.m.

4.8 (15 reviews) +1662-570-1327 Website

420 Columbus Cannabis is a licensed cannabis dispensary in Columbus, Mississippi, rated 4.8 out of 5 across 15 Google reviews, serving dual customers.

420 Columbus Cannabis — quick answers

Is 420 Columbus Cannabis a good dispensary?
420 Columbus Cannabis holds a 4.8-star rating across 15 reviews in Columbus, Mississippi, which places it among the highest-rated dispensaries in its market.
Where is 420 Columbus Cannabis located?
420 Columbus Cannabis is at 2118 Hwy 45 N, Columbus, Mississippi 39705.
What is the phone number for 420 Columbus Cannabis?
You can reach 420 Columbus Cannabis at +1662-570-1327. Call ahead to confirm same-day stock and pickup windows.
Does 420 Columbus Cannabis have an online menu?
Yes. 420 Columbus Cannabis publishes a live menu with current products and pricing, updated by the store itself.

Reviews across the web

Google

4.8(15)

Weedmaps

5.0(43)

Ratings are shown per platform and are never combined into a single score.

About 420 Columbus Cannabis

Located at 2118 Hwy 45 N in Columbus, Mississippi, 420 Columbus Cannabis operates as a dual-licensed dispensary. The store carries products from MidSouth Extracts, Noble Labs, Good Day Farm, Gruv, Southern Sky Brands, Delta Bud Company, and Sweet Life Canna Co. It maintains a 4.8-star rating based on 15 reviews. The facility is open Monday through Saturday from 9:00 a.m. until 7:00 p.m., with Sunday hours running from 9:00 a.m. to 6:00 p.m.

About 420 Columbus Cannabis in Columbus, Mississippi

420 Columbus Cannabis serves Columbus, Mississippi as a dual cannabis dispensary, giving locals and visitors a regulated option without leaving town. The shop is positioned for Columbus residents picking up after work as well as travelers passing through who want a quick, legal stop before heading on. Shoppers report a typical price range of $ on regular menu items.

Why visit 420 Columbus Cannabis

Regulars choose 420 Columbus Cannabis for a strong 4.8 star average across 15 customer reviews, a typical price range of $, a published phone line so you can confirm stock before driving over, and a public website with additional menu details. As a dual retailer, the shop is meant for any qualifying customer per state law, and the staff is used to walking newcomers through dosing, onset times, and what to expect from different product formats.

What to expect at 420 Columbus Cannabis

When you arrive at 2118 Hwy 45 N, expect a standard ID check at the door — this is a regulated Mississippi cannabis dispensary, not a smoke shop. Posted hours are listed in the schedule below; it's smart to leave a buffer near closing time so budtenders can finish your order properly.

Cannabis in Columbus, Mississippi

If you're new to Columbus, Mississippi, 420 Columbus Cannabis is a reasonable first stop for anyone who wants to see what a compliant dual dispensary actually looks like — clean displays, sealed packaging, certificates of analysis on request.

If you're comparing Columbus, Mississippi dispensaries, 420 Columbus Cannabis is worth a look for shoppers who value a regulated, walk-in experience over delivery-only brands. With 15 customer reviews on file averaging 4.8 stars, you can get a sense of staff knowledge, wait times, and value before you decide. As always with cannabis, start low and slow with any new product format and follow Mississippi possession limits.

See more options on the Columbus dispensary directory or browse the full Mississippi dispensary list.

If you're exploring more options around Columbus, you can also compare Apothecarium Green Medical Cannabis Dispensary in Columbus, Holistika in Columbus or The Magg Dispensary in Columbus on Weed Dispos.

Hours

Monday9:00 AM – 7:00 PM
Tuesday9:00 AM – 7:00 PM
Wednesday9:00 AM – 7:00 PM
Thursday9:00 AM – 7:00 PM
Friday9:00 AM – 7:00 PM
Saturday9:00 AM – 7:00 PM
Sunday9:00 AM – 6:00 AM

Location

Get directions to 420 Columbus Cannabis

Full Menu

Browse 420 Columbus Cannabis's live menu with current products and pricing.

5.0on Weedmaps · 43 reviews

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Reviews of 420 Columbus Cannabis

4.8from 13 on-site reviews

Google: 4.8 · 15 reviews

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  • Tyronda Crowell
    May 6, 2026

    Hey, 420 fam this is Ty. I wanted to apologize that our Google says that we open at seven but we in fact open at 9 AM Monday through Saturday and 9 AM to 6 PM on Sunday We do not open at 7

  • Corey Terry
    May 4, 2026

    Tried to stop today on Sunday google says they’re open when arrived they were closed .

  • April Young
    April 17, 2026

    Love love love this place and if T is working she is awesome this place does 35 percent off each day an Friday is 40 percent off they have alot of different brands and very budget friendly.

  • Brooke D
    February 25, 2026

    My girl Ty is always so friendly and knows EXACTLY what i need! Shes the Best ☺️

  • Adam Wilson
    December 6, 2025

    The budtender, Dylan, was very knowledgeable about his products. Every question I had was answered completely and swift. I will be coming back here as many times as I can

Frequently Asked Questions

What kind of dispensary is 420 Columbus Cannabis?
420 Columbus Cannabis is a dual cannabis dispensary in Columbus, Mississippi (ZIP 39705). It serves customers eligible under current state law.
Where exactly is 420 Columbus Cannabis located?
420 Columbus Cannabis is located at 2118 Hwy 45 N, Columbus, Mississippi, 39705. Use the map on this page to get driving directions from anywhere in Columbus.
What are the hours at 420 Columbus Cannabis?
Current opening hours are listed in the Hours section above — check the day you plan to visit and leave time before close so budtenders can complete your order.
Does 420 Columbus Cannabis offer delivery or pickup in Columbus?
Delivery and pickup options vary by week. The fastest way to confirm is to call +1662-570-1327.
Is 420 Columbus Cannabis a good fit for first-time cannabis buyers?
Yes — a licensed dual dispensary like 420 Columbus Cannabis is exactly where new Columbus, Mississippi consumers should start. Budtenders are trained to ask about your experience level, recommend low-dose products, and explain onset time and duration for edibles vs. inhaled formats.
How can I contact 420 Columbus Cannabis?
Phone: +1662-570-1327. Website: https://weedmaps.com/dispensaries/420-columbus. Or visit in person at 2118 Hwy 45 N, Columbus, Mississippi.
What products can you buy at 420 Columbus Cannabis?
420 Columbus Cannabis's current menu on this page lists 148 items, including products from Delta Bud Company, Southern Sky Brands, Sweet Life Canna Co, MidSouth Extracts and Noble Labs. Prices reflect the store's most recent menu sync.

Brands carried at 420 Columbus Cannabis

Each link shows where to buy that brand in Columbus.

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