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Substance (3425 Crater Lake Hwy) — Dispensary in Medford, Oregon

3425 Crater Lake Hwy, Medford, Oregon 97504

5.0· 41 reviews

Best Dispensaries in Medford · WeedDispos Score 66/100 →

dual

Overview

Substance is a dual-licensed dispensary located at 3425 Crater Lake Hwy in Medford, Oregon. This establishment maintains a 5-star rating based on 41 reviews from Google users. The store is categorized within an affordable price range for consumers. Visitors should note that the shop is open daily, beginning at 8:00 a.m. on weekdays and 9:00 a.m. on weekends, with a consistent closing time of 9:00 p.m. every evening.

5.0 (41 reviews) +1541-317-1814 Website

Substance is a licensed cannabis dispensary in Medford, Oregon, rated 5.0 out of 5 across 41 Google reviews, serving dual customers.

Substance — quick answers

Is Substance a good dispensary?
Substance holds a 5.0-star rating across 41 reviews in Medford, Oregon, which places it among the highest-rated dispensaries in its market.
Where is Substance located?
Substance is at 3425 Crater Lake Hwy, Medford, Oregon 97504.
What is the phone number for Substance?
You can reach Substance at +1541-317-1814. Call ahead to confirm same-day stock and pickup windows.
Does Substance have an online menu?
Yes. Substance publishes a live menu with current products and pricing, updated by the store itself.

Reviews across the web

Google

5.0(41)

Ratings are shown per platform and are never combined into a single score.

About Substance

Substance operates as a dual-licensed cannabis store located at 3425 Crater Lake Hwy in Medford, Oregon. The facility holds an affordable price range and maintains a five-star rating based on 41 reviews. Doors open at 8:00 a.m. Monday through Friday and at 9:00 a.m. on Saturdays and Sundays. The shop closes daily at 9:00 p.m.

About Substance in Medford, Oregon

Substance serves Medford, Oregon as a dual cannabis dispensary, giving locals and visitors a regulated option without leaving town. The shop is positioned for Medford residents picking up after work as well as travelers passing through who want a quick, legal stop before heading on. Shoppers report a typical price range of $ on regular menu items.

Why visit Substance

Regulars choose Substance for a strong 5.0 star average across 41 customer reviews, a typical price range of $, a published phone line so you can confirm stock before driving over, and a public website with additional menu details. As a dual retailer, the shop is meant for any qualifying customer per state law, and the staff is used to walking newcomers through dosing, onset times, and what to expect from different product formats.

What to expect at Substance

When you arrive at 3425 Crater Lake Hwy, expect a standard ID check at the door — this is a regulated Oregon cannabis dispensary, not a smoke shop. Posted hours are listed in the schedule below; it's smart to leave a buffer near closing time so budtenders can finish your order properly.

Cannabis in Medford, Oregon

For travelers passing through Medford, Oregon, Substance is a convenient brick-and-mortar option that follows Oregon possession limits and ID requirements you'll want to know before you buy.

If you're comparing Medford, Oregon dispensaries, Substance is worth a look for shoppers who value a regulated, walk-in experience over delivery-only brands. With 41 customer reviews on file averaging 5.0 stars, you can get a sense of staff knowledge, wait times, and value before you decide. As always with cannabis, start low and slow with any new product format and follow Oregon possession limits.

See more options on the Medford dispensary directory or browse the full Oregon dispensary list.

If you're exploring more options around Medford, you can also compare The Spot Cannabis Collective in Medford, Cloud 9 Wellness in Medford or Emerald Triangle Dispensary McAndrews in Medford on Weed Dispos.

Hours

Monday8:00 AM – 9:00 PM
Tuesday8:00 AM – 9:00 PM
Wednesday8:00 AM – 9:00 PM
Thursday8:00 AM – 9:00 PM
Friday8:00 AM – 9:00 PM
Saturday9:00 AM – 9:00 PM
Sunday9:00 AM – 9:00 PM

Location

Get directions to Substance

License, verification & services

Info verified October 18, 2026

Menu

Full Menu

Browse Substance's live menu with current products and pricing.

View Full Menu →

Reviews of Substance

4.9from 15 on-site reviews

Google: 5.0 · 41 reviews

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  • Jerry Boot
    June 9, 2026

    My go to!!! Largest selection in Medford from what I can tell... Customer service is premium!!!

  • Ashley Fernandez
    May 28, 2026

    Leah is awesome!!

  • Alice Trussler
    May 26, 2026

    Amazing staff. Fun to be around.

  • Kalisha M Crawford
    May 26, 2026

    Erica is amazing, such great customer service.

  • Joseph M
    May 21, 2026

    Went in today and the gentleman working the counter was so genuinely kind and knowledgeable. 10/10 experience, i will be going here from now on

Frequently Asked Questions

What kind of dispensary is Substance?
Substance is a dual cannabis dispensary in Medford, Oregon (ZIP 97504). It serves customers eligible under current state law.
Where exactly is Substance located?
Substance is located at 3425 Crater Lake Hwy, Medford, Oregon, 97504. Use the map on this page to get driving directions from anywhere in Medford.
What are the hours at Substance?
Current opening hours are listed in the Hours section above — check the day you plan to visit and leave time before close so budtenders can complete your order.
Does Substance offer delivery or pickup in Medford?
Delivery and pickup options vary by week. The fastest way to confirm is to call +1541-317-1814.
Is Substance a good fit for first-time cannabis buyers?
Yes — a licensed dual dispensary like Substance is exactly where new Medford, Oregon consumers should start. Budtenders are trained to ask about your experience level, recommend low-dose products, and explain onset time and duration for edibles vs. inhaled formats.
How can I contact Substance?
Phone: +1541-317-1814. Website: https://www.substancemarket.com/. Or visit in person at 3425 Crater Lake Hwy, Medford, Oregon.

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