What kind of dispensary is Root 66 Dispensary - South Grand, MO?

Root 66 Dispensary - South Grand, MO is a dual cannabis dispensary in St. Louis, Missouri (ZIP 63118). It serves customers eligible under current state law.

Where exactly is Root 66 Dispensary - South Grand, MO located?

Root 66 Dispensary - South Grand, MO is located at 3737 S Grand Blvd, St. Louis, Missouri, 63118. Use the map on this page to get driving directions from anywhere in St. Louis.

What are the hours at Root 66 Dispensary - South Grand, MO?

Current opening hours are listed in the Hours section above — check the day you plan to visit and leave time before close so budtenders can complete your order.

Does Root 66 Dispensary - South Grand, MO offer delivery or pickup in St. Louis?

Delivery and pickup options vary by week. The fastest way to confirm is to call +1314-257-0816.

Is Root 66 Dispensary - South Grand, MO a good fit for first-time cannabis buyers?

Yes — a licensed dual dispensary like Root 66 Dispensary - South Grand, MO is exactly where new St. Louis, Missouri consumers should start. Budtenders are trained to ask about your experience level, recommend low-dose products, and explain onset time and duration for edibles vs. inhaled formats.

How can I contact Root 66 Dispensary - South Grand, MO?

Phone: +1314-257-0816. Website: https://root66cannabis.com/south-grand-location/. Or visit in person at 3737 S Grand Blvd, St. Louis, Missouri.

Root 66 Dispensary - South Grand, MO — Dispensary in St. Louis, Missouri

Name: Root 66 Dispensary - South Grand, MO
Address: 3737 S Grand Blvd, St. Louis, Missouri, 63118, US
Telephone: +1314-257-0816
Price range: $
Rating: 4.7

3737 S Grand Blvd, St. Louis, Missouri 63118

4.7· 621 reviews

Best Dispensaries in St. Louis · WeedDispos Score 78/100 →

dual

Overview

Root 66 Dispensary is a dual-licensed retail location situated at 3737 S Grand Blvd in St. Louis, Missouri. The establishment holds a 4.7-star rating from 621 Google reviewers and a 4.4-star rating from 14 Weedmaps reviewers. This store is categorized as a low-price option for consumers. For those planning a visit, the dispensary maintains consistent daily operating hours from 8:00 a.m. until 10:00 p.m. throughout the entire week.

4.7 (621 reviews) +1314-257-0816 Website

Root 66 Dispensary - South Grand, MO is a licensed cannabis dispensary in St. Louis, Missouri, rated 4.7 out of 5 across 621 Google reviews, serving dual customers.

Root 66 Dispensary - South Grand, MO — quick answers

Is Root 66 Dispensary - South Grand, MO a good dispensary?: Root 66 Dispensary - South Grand, MO holds a 4.7-star rating across 621 reviews in St. Louis, Missouri, which places it among the highest-rated dispensaries in its market.
Where is Root 66 Dispensary - South Grand, MO located?: Root 66 Dispensary - South Grand, MO is at 3737 S Grand Blvd, St. Louis, Missouri 63118.
What is the phone number for Root 66 Dispensary - South Grand, MO?: You can reach Root 66 Dispensary - South Grand, MO at +1314-257-0816. Call ahead to confirm same-day stock and pickup windows.
Does Root 66 Dispensary - South Grand, MO have an online menu?: Yes. Root 66 Dispensary - South Grand, MO publishes a live menu with current products and pricing, updated by the store itself.

Reviews across the web

Google

4.7(621)

Weedmaps

4.4(14)

Ratings are shown per platform and are never combined into a single score.

About Root 66 Dispensary - South Grand, MO

Root 66 Dispensary - South Grand is a dual-licensed facility located at 3737 S Grand Blvd in St. Louis, Missouri. The business operates as both a cannabis store and an herbal medicine store. Visitors can expect daily hours from 8:00 a.m. to 10:00 p.m. This location is currently identified by a $ price range and holds an average rating of 4.7 out of 5 based on 621 reviews.

About Root 66 Dispensary - South Grand, MO in St. Louis, Missouri

Inside the St. Louis market, Root 66 Dispensary - South Grand, MO operates under Missouri dual licensing — a meaningful distinction for shoppers who want compliant, tested product instead of the gray market. The shop is positioned for St. Louis residents picking up after work as well as travelers passing through who want a quick, legal stop before heading on. Shoppers report a typical price range of $ on regular menu items.

Why visit Root 66 Dispensary - South Grand, MO

Regulars choose Root 66 Dispensary - South Grand, MO for a strong 4.7 star average across 621 customer reviews, a typical price range of $, a published phone line so you can confirm stock before driving over, and a public website with additional menu details. As a dual retailer, the shop is meant for any qualifying customer per state law, and the staff is used to walking newcomers through dosing, onset times, and what to expect from different product formats.

What to expect at Root 66 Dispensary - South Grand, MO

When you arrive at 3737 S Grand Blvd, expect a standard ID check at the door — this is a regulated Missouri cannabis dispensary, not a smoke shop. Posted hours are listed in the schedule below; it's smart to leave a buffer near closing time so budtenders can finish your order properly.

Cannabis in St. Louis, Missouri

For travelers passing through St. Louis, Missouri, Root 66 Dispensary - South Grand, MO is a convenient brick-and-mortar option that follows Missouri possession limits and ID requirements you'll want to know before you buy.

Planning a trip to Root 66 Dispensary - South Grand, MO? St. Louis shoppers tend to bundle a stop here with errands nearby, so it pays to check live menu availability before you go — a quick call to +1314-257-0816 confirms what's actually in the case today. Missouri law requires valid ID at entry, posted purchase limits at the register, and child-resistant exit packaging, all of which Root 66 Dispensary - South Grand, MO follows as a licensed dual retailer.

See more options on the St. Louis dispensary directory or browse the full Missouri dispensary list.

If you're exploring more options around St. Louis, you can also compare Bodega Bros Dispensary in St. Louis, The Forest Dispensary - St. Louis in St. Louis or SWADE Dispensary Cherokee in St. Louis on Weed Dispos.

Hours

Monday	8:00 AM – 10:00 PM
Tuesday	8:00 AM – 10:00 PM
Wednesday	8:00 AM – 10:00 PM
Thursday	8:00 AM – 10:00 PM
Friday	8:00 AM – 10:00 PM
Saturday	8:00 AM – 10:00 PM
Sunday	8:00 AM – 10:00 PM

Location

Get directions to Root 66 Dispensary - South Grand, MO

License, verification & services

Info verified October 18, 2026

Reviews of Root 66 Dispensary - South Grand, MO

4.2from 13 on-site reviews

Google: 4.7 · 621 reviews

5★: 10
4★: 0
3★: 0
2★: 1
1★: 2

Sort by

Donald Fowler
July 21, 2026
I really like this place,for obvious reasons. If you want too feel comfortable and at ease,this is the place. From the manager to the staff everyone is well trained to help you decide what you want 😉
Kay
June 29, 2026
Kris the best
Kimberly Carter
June 24, 2026
They are good
kiaa Babyy
June 19, 2026
Love the store 💕
Momma Cannon
May 31, 2026
Nice workers
Wilkins Jackson
May 4, 2026
Great Vibes and premium guidance provided, courtesy of TJ & Mike. Definitely will be returning!
Dayan McCormick (Instagram DayansBalance)
April 2, 2026
I have been having difficulty sleeping for about 4 months & the sleeping pills just stopped working so I was desperate to sleep at this point. My career requires me to be at my best & when one lacks major sleep, life gets weird😐 I had to speak to a lot of people that use cannabis for sleep before I came in. They have Fantastic Customer Service, everyone is very knowledgeable and will be back! FYI, you obviously need a valid ID, they only take cash or Dutchie pay. They do have ATM & there is a $3.50 service fee to withdraw money. I took one Gummie at 8:30pm & by 8:40p I felt it kicking in. I will continue to purchase from here. You Guys Rock 🤘🏽
Chuck Bogardus
April 1, 2026
Nice location.
Zack Hubert
March 30, 2026
Awesome service with an attention to detail
Erica
March 5, 2026
I gave too stars because the place is an acceptable place to shop at but when I hear about underpaid over worked workers it makes me not want to shop there anymore security guards can not keep the place safe if they are over worked they should be getting off of work at scheduled times the managers should be filling in the gaps I'm not sure if I will come back because as a customer I tlk to the people behind the window so we establish a relationship I dont think it's fair for me to spend my money in places like this ...this goes for all unseen workers
Darryl Walker
January 23, 2026
First time there and I WAS THE ONE WITH AN ISSUE...ugh...first time there..by the way..nice... young lady showed me gummies and recommended a few. I told her an issue I have with certain packaging and she completely helped...went to pay and ...stupid credit card acting up..wind up having to leave and come back to complete the purchase..they still had my order ready... I'm sold on this place, great deal, great employees, great products, reasonable priced...terrific job *****
T M
December 14, 2025
Trying to pass THC-A off as THC. Unknowledgable staff. THC-A transfers to only 87% THC when smoked. So you 24% THC-A is coming out at approximately 16% THC. Despite explaining this to staff, I was still given one varity that was mostly THC-A. NOT primary THC. There is a difference. As a visually impaired person I rely on knowledgeable staff to be my eyes. It was only after arriving home with a magnifying glass could I witness this. Over priced. Skip.
ban Snow
December 7, 2025
only issue with that location is the security guards very rude Seems like they That's why I stopped going there you want a better experience find a different location

Frequently Asked Questions

What kind of dispensary is Root 66 Dispensary - South Grand, MO?: Root 66 Dispensary - South Grand, MO is a dual cannabis dispensary in St. Louis, Missouri (ZIP 63118). It serves customers eligible under current state law.
Where exactly is Root 66 Dispensary - South Grand, MO located?: Root 66 Dispensary - South Grand, MO is located at 3737 S Grand Blvd, St. Louis, Missouri, 63118. Use the map on this page to get driving directions from anywhere in St. Louis.
What are the hours at Root 66 Dispensary - South Grand, MO?: Current opening hours are listed in the Hours section above — check the day you plan to visit and leave time before close so budtenders can complete your order.
Does Root 66 Dispensary - South Grand, MO offer delivery or pickup in St. Louis?: Delivery and pickup options vary by week. The fastest way to confirm is to call +1314-257-0816.
Is Root 66 Dispensary - South Grand, MO a good fit for first-time cannabis buyers?: Yes — a licensed dual dispensary like Root 66 Dispensary - South Grand, MO is exactly where new St. Louis, Missouri consumers should start. Budtenders are trained to ask about your experience level, recommend low-dose products, and explain onset time and duration for edibles vs. inhaled formats.
How can I contact Root 66 Dispensary - South Grand, MO?: Phone: +1314-257-0816. Website: https://root66cannabis.com/south-grand-location/. Or visit in person at 3737 S Grand Blvd, St. Louis, Missouri.

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