What kind of dispensary is Root 66 Dispensary – Dogtown, MO?

Root 66 Dispensary – Dogtown, MO is a dual cannabis dispensary in St. Louis, Missouri (ZIP 63139). It serves customers eligible under current state law.

Where exactly is Root 66 Dispensary – Dogtown, MO located?

Root 66 Dispensary – Dogtown, MO is located at 6660 Manchester Ave, St. Louis, Missouri, 63139. Use the map on this page to get driving directions from anywhere in St. Louis.

What are the hours at Root 66 Dispensary – Dogtown, MO?

Current opening hours are listed in the Hours section above — check the day you plan to visit and leave time before close so budtenders can complete your order.

Does Root 66 Dispensary – Dogtown, MO offer delivery or pickup in St. Louis?

Delivery and pickup options vary by week. The fastest way to confirm is to call +1314-282-7978.

Is Root 66 Dispensary – Dogtown, MO a good fit for first-time cannabis buyers?

Yes — a licensed dual dispensary like Root 66 Dispensary – Dogtown, MO is exactly where new St. Louis, Missouri consumers should start. Budtenders are trained to ask about your experience level, recommend low-dose products, and explain onset time and duration for edibles vs. inhaled formats.

How can I contact Root 66 Dispensary – Dogtown, MO?

Phone: +1314-282-7978. Website: https://root66cannabis.com/dogtown-location/. Or visit in person at 6660 Manchester Ave, St. Louis, Missouri.

Root 66 Dispensary – Dogtown, MO — Dispensary in St. Louis, Missouri

Name: Root 66 Dispensary – Dogtown, MO
Address: 6660 Manchester Ave, St. Louis, Missouri, 63139, US
Telephone: +1314-282-7978
Price range: $
Rating: 4.8

6660 Manchester Ave, St. Louis, Missouri 63139

4.8· 943 reviews

Ranked #8 of the best dispensaries in St. Louis · WeedDispos Score 81/100 →

dual

Overview

Root 66 Dispensary is a dual-licensed establishment located at 6660 Manchester Ave in St. Louis, Missouri. The store holds a 4.8-star rating from 943 Google reviewers and a 5-star rating based on 4 reviews on Weedmaps. Customers can expect a budget-friendly price range for their purchases. The facility operates daily with consistent hours from 8:00 a.m. until midnight throughout the entire week.

4.8 (943 reviews) +1314-282-7978 Website

Root 66 Dispensary – Dogtown, MO is a licensed cannabis dispensary in St. Louis, Missouri, rated 4.8 out of 5 across 943 Google reviews, serving dual customers.

Root 66 Dispensary – Dogtown, MO — quick answers

Is Root 66 Dispensary – Dogtown, MO a good dispensary?: Root 66 Dispensary – Dogtown, MO holds a 4.8-star rating across 943 reviews in St. Louis, Missouri, which places it among the highest-rated dispensaries in its market.
Where is Root 66 Dispensary – Dogtown, MO located?: Root 66 Dispensary – Dogtown, MO is at 6660 Manchester Ave, St. Louis, Missouri 63139.
What is the phone number for Root 66 Dispensary – Dogtown, MO?: You can reach Root 66 Dispensary – Dogtown, MO at +1314-282-7978. Call ahead to confirm same-day stock and pickup windows.
Does Root 66 Dispensary – Dogtown, MO have an online menu?: Yes. Root 66 Dispensary – Dogtown, MO publishes a live menu with current products and pricing, updated by the store itself.

Reviews across the web

Google

4.8(943)

Weedmaps

5.0(4)

Ratings are shown per platform and are never combined into a single score.

About Root 66 Dispensary – Dogtown, MO

Root 66 Dispensary – Dogtown, MO, operates as a dual-licensed facility located at 6660 Manchester Ave in St. Louis, Missouri. Categorized as both a cannabis and herbal medicine store, the business serves customers daily from 8:00 a.m. until midnight. This location maintains a $ price range and has received a 4.8 out of 5 rating based on 943 reviews.

About Root 66 Dispensary – Dogtown, MO in St. Louis, Missouri

Root 66 Dispensary – Dogtown, MO's St. Louis, Missouri storefront sits inside Missouri's regulated dual program, with seed-to-sale tracked inventory and posted retail hours. The shop is positioned for St. Louis residents picking up after work as well as travelers passing through who want a quick, legal stop before heading on. Shoppers report a typical price range of $ on regular menu items.

Why visit Root 66 Dispensary – Dogtown, MO

Regulars choose Root 66 Dispensary – Dogtown, MO for a strong 4.8 star average across 943 customer reviews, a typical price range of $, a published phone line so you can confirm stock before driving over, and a public website with additional menu details. As a dual retailer, the shop is meant for any qualifying customer per state law, and the staff is used to walking newcomers through dosing, onset times, and what to expect from different product formats.

What to expect at Root 66 Dispensary – Dogtown, MO

When you arrive at 6660 Manchester Ave, expect a standard ID check at the door — this is a regulated Missouri cannabis dispensary, not a smoke shop. Posted hours are listed in the schedule below; it's smart to leave a buffer near closing time so budtenders can finish your order properly.

Cannabis in St. Louis, Missouri

Cannabis retail in St. Louis has matured quickly, and shops like Root 66 Dispensary – Dogtown, MO are part of why local consumers no longer have to drive across state lines or rely on the unlicensed market.

For St. Louis regulars, Root 66 Dispensary – Dogtown, MO fits into the broader Missouri cannabis landscape as a compliant dual option with seed-to-sale traceability and lab-tested SKUs. and the menu rotates often enough that even regulars usually find something new on the shelf — new strain drops, fresh concentrate batches, or limited edible runs from in-state brands.

See more options on the St. Louis dispensary directory or browse the full Missouri dispensary list.

If you're exploring more options around St. Louis, you can also compare Kind Goods Recreational Dispensary - On The Hill in St. Louis, Hi-Pointe Cannabis Dispensary in St. Louis or Codes Dispensary St. Louis Hampton in St. Louis on Weed Dispos.

Hours

Monday	8:00 AM – 12:00 AM
Tuesday	8:00 AM – 12:00 AM
Wednesday	8:00 AM – 12:00 AM
Thursday	8:00 AM – 12:00 AM
Friday	8:00 AM – 12:00 AM
Saturday	8:00 AM – 12:00 AM
Sunday	8:00 AM – 12:00 AM

Location

Get directions to Root 66 Dispensary – Dogtown, MO

License, verification & services

Info verified October 18, 2026

Reviews of Root 66 Dispensary – Dogtown, MO

4.9from 15 on-site reviews

Google: 4.8 · 943 reviews

5★: 14
4★: 1
3★: 0
2★: 0
1★: 0

Sort by

Crazy Bitch
July 31, 2026
Great place good with ppl
Courtney Rogers
July 22, 2026
Always great staff. Love that they are 24 hours.
Alexis Crane
July 16, 2026
Amazing first time experience. Cedric was awesome and v helpful
Raneisha G
July 16, 2026
Lillie great customer service!
Josie Adair
July 15, 2026
Grayson was one of the best bud tenders ever! He helped me get everything I needed and wanted plus more! Please stop by and check them out! Smooth easy, in and out process!
Nicki Island
July 14, 2026
Cedric is the shiiiiiiiit❤️
Courtney Wayda
July 7, 2026
Always fast with friendly staff!!
Bella Marie
June 30, 2026
Cedric was very helpful and patient . I will be back!
Sandy Roberts
June 28, 2026
The deals are great. The people that work there are some of the most professional and kindest people in the dispensary business. Everyone deserves a promotion!!
Kati Frazier
June 19, 2026
Cedric is the best! Love this location.
meware07
June 13, 2026
Cedric is the best! So helpful!
DaVante and Gabrielle
June 13, 2026
Super dope!
Taylor Humber
June 6, 2026
The absolute experience! Cedric hooked it up and understood the assignment. I can always appreciate superb customer service and great recommendations. Come on down for the hook up.
Mark Harris
June 6, 2026
Very informative and very helpful my experience was very pleasant I will definitely be returning
Ja’Wuan Barner
June 6, 2026
Cedrick showed great customer service and answered any and all questions i had. 10/10 service

Frequently Asked Questions

What kind of dispensary is Root 66 Dispensary – Dogtown, MO?: Root 66 Dispensary – Dogtown, MO is a dual cannabis dispensary in St. Louis, Missouri (ZIP 63139). It serves customers eligible under current state law.
Where exactly is Root 66 Dispensary – Dogtown, MO located?: Root 66 Dispensary – Dogtown, MO is located at 6660 Manchester Ave, St. Louis, Missouri, 63139. Use the map on this page to get driving directions from anywhere in St. Louis.
What are the hours at Root 66 Dispensary – Dogtown, MO?: Current opening hours are listed in the Hours section above — check the day you plan to visit and leave time before close so budtenders can complete your order.
Does Root 66 Dispensary – Dogtown, MO offer delivery or pickup in St. Louis?: Delivery and pickup options vary by week. The fastest way to confirm is to call +1314-282-7978.
Is Root 66 Dispensary – Dogtown, MO a good fit for first-time cannabis buyers?: Yes — a licensed dual dispensary like Root 66 Dispensary – Dogtown, MO is exactly where new St. Louis, Missouri consumers should start. Budtenders are trained to ask about your experience level, recommend low-dose products, and explain onset time and duration for edibles vs. inhaled formats.
How can I contact Root 66 Dispensary – Dogtown, MO?: Phone: +1314-282-7978. Website: https://root66cannabis.com/dogtown-location/. Or visit in person at 6660 Manchester Ave, St. Louis, Missouri.

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